The evidence that cold cap therapy works
Published: March 10, 2025
One of the most distressing side effects of chemotherapy is hair loss. In fact, a study published in Skin Appendage Disorders found that 14% of women would consider refusing chemotherapy due to the fear of losing their hair.
However, evidence for cold cap therapy demonstrates that this treatment can significantly reduce hair loss, allowing patients to maintain their sense of identity and confidence during cancer treatment.
Although cold cap therapy, also known as scalp cooling, has been available for over two decades, it has only recently gained broader recognition in the medical field. Many oncologists now advocate for a more holistic approach to treatment – one that considers not just the disease but also the patient’s emotional and psychological well-being. Preserving hair during chemotherapy can help maintain a positive mindset, which is crucial for recovery.
This article explores the science behind cold capping, highlights the evidence for cold cap therapy, and shares real-life patient experiences.
Understanding Cold Capping
Cold cap therapy involves wearing specialized caps cooled to very low temperatures before, during, and after chemotherapy sessions. The cooling constricts blood vessels in the scalp, reducing the amount of chemotherapy drugs that reach hair follicles and thereby minimizing hair loss.
Research Supporting Cold Cap Therapy
Numerous studies provide evidence for cold cap therapy, particularly for breast cancer patients undergoing chemotherapy. Here are some key findings:
Ohio Health
Retrospective evaluation of Penguin Cold Caps for chemotherapy-induced alopecia
- 75% of patients saved more than 75% of their hair when using the Penguin Cold Cap system
- 75% of patients retained more than 75% of their hair using the Penguin Cold Cap system.
- 92% of participants retained at least 50% of their hair.
- Success rates varied depending on the chemotherapy regimen.
- 71.4% success for those on doxorubicin-based treatments.
- 95.7% success for paclitaxel.
- 96.6% success for docetaxel.
- The overall effectiveness of 92.1% aligns with or surpasses previous studies.
Find out more: Ohio health
Clinical Breast Cancer Investigation
- 65% of patients experienced less than 25% hair loss (considered an “excellent” outcome).
- 25% reported moderate hair loss (between 25% and 50%).
- The study confirmed that scalp cooling is highly effective in preventing chemotherapy-induced hair loss.
Find out more: Clinical Breast Cancer Investigation Results
Providence St Joseph Health
- 80% of participants achieved at least 50% hair retention using the Penguin Cold Cap system.
- Patients also reported improved emotional well-being and a more positive outlook post-treatment.
Find out more: Providence St Joseph Health Study Results
Turkish Journal of Oncology
- A meta-analysis of five studies found that 78.5% of patients experienced no significant hair loss.
Find out more: Turkish Journal of Oncology Article
Breast Cancer Research and Treatment
- 61% of patients retained their hair using Penguin Cold Caps.
- Satisfaction rates ranged from 74% to 100%.
- Every patient who completed scalp cooling recommended the therapy.
Find out more: Breast Cancer Research and Treatment, Clinical Trial Results
European Journal of Cancer
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An 81% overall hair protection rate was reported in a study analyzing the impact of scalp cooling on patients receiving taxanes, anthracyclines, and etoposide—three of the most aggressive chemotherapy drugs.
Find out more: European Journal of Cancer Article
Patient experiences
In addition to scientific evidence, patient testimonials provide valuable insights into the success of cold capping. Here are a few excerpts from breast cancer survivors who used Penguin Cold Caps during their treatment:
Jennifer’s last day of chemo
Jennifer’s story
Diagnosed with breast cancer, Jennifer underwent weekly rounds of Taxol and Herceptin while using cold cap therapy. She shared:
“My hair looks amazing—super healthy, lots of growth, and most importantly, I still look like me.”
Meg’s journey
After receiving a multiple myeloma diagnosis in 2023, Meg turned to cold cap therapy to maintain her hair. She said:
“Receiving my cancer diagnosis was hard enough, but losing my hair felt like too much. I am so happy with my results—I kept a positive attitude, and it worked!”
Liesl’s experience
Liesl retained 95% of her hair with cold cap therapy and has since become an advocate for the treatment. She stated:
“Since my first session, I’ve told everyone about cold capping—including strangers and online support groups. Every woman facing chemotherapy should know that saving her hair is an option.”
To find out why more patients are successful with Penguin Cold caps, click on the button:
Cold capping is a proven technique
Cold cap therapy is a game-changer for chemotherapy patients. Research and patient experiences provide compelling evidence for cold cap therapy, proving it to be an effective tool for preserving hair and boosting emotional resilience during treatment.
However, while cold capping has shown great success, it may not be suitable for everyone. Factors such as chemotherapy drug type, dosage, and individual patient characteristics can impact effectiveness. Consulting with a healthcare provider is essential to determine if this treatment is the right option.
To find out more, request a call back from a representative in your area – just complete the form below.